Search results for "ApoE gene"

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Identification Of P.Leu167Del Apoe Gene Mutation By Next Generation Sequencing In A Large Hypercholesterolemic Family

2019

Apolipoprotein EGeneticsSettore MED/09 - Medicina InternaNEXT GENERATION SEQUENCING HYPERCHOLESTEROLEMIAMutation (genetic algorithm)APOE GENEIdentification (biology)BiologyCardiology and Cardiovascular MedicineMUTATIONDNA sequencingAtherosclerosis
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ApoE polymorphism in a small Mediterranean island: Relationships with plasma lipids, lipoproteins and LDL particle size

2001

Polymorphisms of apoE gene are able to modulate lipoprotein metabolism at different steps and to influence LDL-cholesterol (LDL-C) levels and also other lipoproteins features. Population studies documented large differences in the frequency of apoE alleles which could be even related to the prevalence of cardiovascular disease. In this study we evaluated the apoE genotypes and allele frequency in 576 subjects living in a small island in the Tyrrhenian Sea and the relative contribution of apoE polymorphism on plasma lipid and lipoprotein profile, including LDL particle size. We found a cumulative frequency of 0.073, 0.866 and 0.061 for ε2, ε3 and ε4 alleles respectively. Moreover ε3 subjects…

Settore MED/09 - Medicina InternaApoE gene Lipoproteins LDL particle size Mediterranean population
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